ISMP suffered a profound loss on April 21, 2021, when our remarkable colleague and ISMP Medical Director, Ronald S. Litman, DO, ML, passed away after a long struggle with acute myeloid leukemia. He was 62 years old. Ron was an internationally known pediatric anesthesiologist at Children’s Hospital of Philadelphia (CHOP) and professor of anesthesiology and pediatrics at the Perelman School of Medicine at the University of Pennsylvania. In addition, he served as medical director for the Malignant Hyperthermia Association of the United States (MHAUS) and was a recent chairperson of the US Food and Drug Administration (FDA) Anesthetic and Analgesic Drug Products Advisory Committee. He was also editor of the textbook, Basics of Pediatric Anesthesia. Ron’s intense interest in medication safety made him a valuable member of the ISMP team. He would always make himself available as an educator and lecturer. Just a week before his passing, Ron participated as a speaker for ISMP during a webinar on the use of smart pump data to improve perioperative medication safety. As a friend and a colleague, we will always cherish the memories of his kindness, quick wit, and genuine desire to make healthcare safer. We miss him dearly and offer our deepest condolences to his family.