en-556 What makes mRNA vaccine safe?
Created on Sunday, 07 March 2021
Modified on 06 June 2021
556
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The vaccine safety derives from its mechanism of action. Indeed :
- Anti- COVID19 mRNA vaccines convey only one strand of messenger RNA instead of the whole viral RNA in a viral infection. This mRNA encodes only one protein, the Spike protein which is immunostimulant and non-pathogenic. The low risks associated with inactivated or attenuated viruses in conventional vaccines, are therefore irrelevant to these mRNA vaccines.The vaccine mRNA is free of all viral components,since it was synthesized in laboratories where the virus itself never entered.
- After cell penetration, the vaccine mRNA remains in the cytoplasm, and being very labile, it is qickly eliminated. It never enters the nucleus, has no contact with DNA, and no access to the keys that allow interaction with DNA especially reverse transcriptase. This point is confirmed by all regulatory agencies that have granted emergency use authorization (FDA, EMA, MHRA.): mRNA does not enter the nucleus and it cannot act on the human genome.
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